Protein folding stability measured at scale

Protein folding stability measured at scale

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https://www.pnas.org/cms/10.1073/pnas.1411798111/asset/8fe64cca-d41b-47c0-a1de-fc2fc0360c0a/assets/graphic/pnas.1411798111fig03.jpeg

The nature of protein folding pathways

https://www.cell.com/cms/attachment/a75ffc3b-ecca-4a2e-8331-0da27dee6186/gr1.jpg

Determining and interpreting protein lifetimes in mammalian tissues: Trends in Biochemical Sciences

https://www.science.org/cms/10.1126/science.aan0693/asset/3536e302-27d6-422b-8c88-fca3b2453c2b/assets/graphic/357_168_f4.jpeg

Global analysis of protein folding using massively parallel design, synthesis, and testing

https://www.cell.com/cms/attachment/cb152bd5-ed0c-4520-9c9e-dc9a1acb2565/gr1.jpg

Nature and Regulation of Protein Folding on the Ribosome: Trends in Biochemical Sciences

https://pubs.acs.org/cms/10.1021/ja044449u/asset/images/medium/ja044449un00001.gif

Scaling of Folding Times with Protein Size

https://ars.els-cdn.com/content/image/1-s2.0-S2405471221001952-gr1.jpg

Fundamentals to function: Quantitative and scalable approaches for measuring protein stability - ScienceDirect

https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41598-017-08385-0/MediaObjects/41598_2017_8385_Fig1_HTML.jpg

Directly monitor protein rearrangement on a nanosecond-to-millisecond time- scale

https://pubs.acs.org/cms/10.1021/ja808843h/asset/images/large/ja-2008-08843h_0002.jpeg

Protein Folding Rates and Stability: How Much Is There Beyond Size?

https://cdnintech.com/media/chapter/20166/1512345123/media/image57.png

The Stability of a Three-State Unfolding Protein

https://ars.els-cdn.com/content/image/1-s2.0-S1570963918302152-gr1.jpg

A one-pot analysis approach to simplify measurements of protein stability and folding kinetics - ScienceDirect

https://www.pnas.org/cms/10.1073/pnas.2122676119/asset/e47feecb-67b9-4831-9489-6460af985465/assets/images/large/pnas.2122676119fig05.jpg

Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation

https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41467-019-09088-y/MediaObjects/41467_2019_9088_Fig1_HTML.png

Quantifying protein dynamics and stability in a living organism

https://sites.duke.edu/fitzgeraldlab/files/2023/04/mfac098fig1g-300x173.jpeg

Publications The Fitzgerald Lab

https://iiif.elifesciences.org/lax:82593%2Felife-82593-fig2-v2.tif/full/1500,/0/default.jpg

Rapid protein stability prediction using deep learning representations